Runs a decrepit hotel, home to vermin (7)
I believe the answer is:
rathole
'home to vermin' is the definition.
(home for rats)
'runs a decrepit hotel' is the wordplay.
'runs' becomes 'r' (cricket abbreviation).
'decrepit' indicates anagramming the letters.
'hotel' is an anagram of 'thole'.
'r'+'a'+'thole'='RATHOLE'
(Other definitions for rathole that I've seen before include "Sign of infestation" , "squalid room" , "Dirty room" , "Rodent entrance" , "pit" .)