Runs out in shortage? That’s the end (5)
I believe the answer is:
death
'the end' is the definition.
(the end of a life)
'runs out in shortage?' is the wordplay.
'runs' becomes 'r' (cricket abbreviation).
'out in' suggests deleting specific letters.
'shortage?' becomes 'dearth' (dearth can mean a shortage or lack).
'dearth' with 'r' taken away is 'DEATH'.
'that's' is the link.
(Other definitions for death that I've seen before include "Final moments" , "The end - after 13 across, the plague" , ""The last enemy"" , "Last moment of existence" , "Extinction" .)