Crossword Genius

S American city (3)

Ross

I believe the answer is:

rio

(Other definitions for rio that I've seen before include "A Mexican river, may be grande" , "Location of next Olympic Games, in short" , "Manchester United player in South American city, in short?" , "old capital" , "Erstwhile home of Biggs" .)

I've seen this clue in The Mirror.
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