Saatchi's opening with good artist occasionally making animation (6)
I believe the answer is:
spirit
'animation' is the definition.
(both can mean liveliness)
'saatchi's opening with good artist occasionally' is the wordplay.
'opening' indicates taking the first letters.
'with' says to put letters next to each other.
'good' becomes 'pi' (old-fashioned term for pious).
'occasionally' means one should take alternating letters.
The initial letter of 'saatchi' is 's'.
The alternating letters of 'artist' are 'rit'.
's'+'pi'+'rit'='SPIRIT'
'making' is the link.
(Other definitions for spirit that I've seen before include "Spectre - alcohol" , "Supernatural being without a body" , "Strong distilled alcohol" , "Enthusiastic ghost" , "Vivacity" .)