Sack cleaner holding up key centre of worship (10)
I believe the answer is:
tabernacle
'centre of worship' is the definition.
(Mormon place of worship)
'sack cleaner holding up key' is the wordplay.
'sack' indicates anagramming the letters (sack can mean destroy or spoil).
'holding up' is a charade indicator (letters next to each other) (some letters go underneath or hold up others).
'key' becomes 'tab' (key on a computer keyboard).
'cleaner' anagrammed gives 'ernacle'.
'ernacle' after 'tab' is 'TABERNACLE'.
(Other definitions for tabernacle that I've seen before include "Tent for Ark in Exodus" , "Nonconformist church" , "sanctuary" , "Portable tent" , "Place of worship; sacrament box" .)