Sack Virginia in frenzy (6)
I believe the answer is:
ravage
'sack' is the definition.
(I've seen this in another clue)
'virginia in frenzy' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'in' means one lot of letters goes inside another.
'frenzy' becomes 'rage' (I've seen this before).
'va' placed inside 'rage' is 'RAVAGE'.
(Other definitions for ravage that I've seen before include "Greatly damage, destroy" , "Pillage or lay waste" , "Act like a 6" , "Sack" , "Lay waste, plunder" .)