Safe remedy, following directions (6)
I believe the answer is:
secure
'safe' is the definition.
(synonyms)
'remedy following directions' is the wordplay.
'remedy' becomes 'cure' (synonyms).
'following' is a charade indicator (letters next to each other).
'directions' becomes 'se' (I've seen this in other clues).
'cure' put after 'se' is 'SECURE'.
(Other definitions for secure that I've seen before include "'Safe, confident (6)'" , "land" , "Reliable; firmly fixed" , "Safe; fixed" , "Incapable of being tampered with" .)