Safe to see surrounding canine (6)
I believe the answer is:
secure
'safe' is the definition.
(I know that safe can be written as secure)
'see surrounding canine' is the wordplay.
'surrounding' means one lot of letters goes inside another.
'canine' becomes 'cur' (both can mean a despicable person).
'see' enclosing 'cur' is 'SECURE'.
'to' acts as a link.
(Other definitions for secure that I've seen before include "lock" , "Reliable; firmly fixed" , "Firmly in place - free from danger" , "Seize; make fast" , "Safe and well-protected" .)