Safety from nepotic rot in new order (10)
I believe the answer is:
protection
'safety' is the definition.
(protection is a kind of safety)
'nepotic rot in new order' is the wordplay.
'in new order' indicates an anagram (I've seen this in other clues).
'nepotic'+'rot'='nepoticrot'
'nepoticrot' is an anagram of 'PROTECTION'.
'from' acts as a link.
(Other definitions for protection that I've seen before include "Defence; patronage" , "Way to extort money criminally" .)