Salami, off at the end, causes unease (7)
I believe the answer is:
malaise
'unease' is the definition.
(I know that unease can be written as malaise)
'salami off at the end' is the wordplay.
'off' indicates anagramming the letters.
'at' says to put letters next to each other.
'end' suggests the final letters.
The final letter of 'the' is 'e'.
'salami' with letters rearranged gives 'malais'.
'malais'+'e'='MALAISE'
'causes' acts as a link.
(Other definitions for malaise that I've seen before include "flu perhaps" , "Disquiet" , "General feeling of unease or illness" , "Uneasy feeling" , "General feeling of discomfort" .)