Sanctimonious article supporting southern city (4)
I believe the answer is:
pisa
'city' is the definition.
(Pisa is an example)
'sanctimonious article supporting southern' is the wordplay.
'sanctimonious' becomes 'pi'.
'article' becomes 'a' (indefinite article).
'supporting' is a charade indicator (letters next to each other) (in a down clue, some letters go below others).
'southern' becomes 's' (abbreviation).
'a' after 's' is 'sa'.
'pi'+'sa'='PISA'
(Other definitions for pisa that I've seen before include "There's a marked inclination here" , "City in Tuscany" , "Location of leaning tower" , "Site of the famous leaning tower" , "Italian city with leaning tower" .)