Sap is wrong supporting rise of Queen (5)
I believe the answer is:
resin
'sap' is the definition.
(I've seen this before)
'wrong supporting rise of queen' is the wordplay.
'wrong' becomes 'sin' (I've seen this before).
'supporting' means one lot of letters go next to another (in a down clue, some letters go below others).
'rise of' shows that the letters should be reversed in order.
'queen' becomes 'er' (abbreviation for Elizabeth Regina).
'er' reversed gives 're'.
'sin' after 're' is 'RESIN'.
'is' acts as a link.
(Other definitions for resin that I've seen before include "component of varnish" , "Material exuded from tree" , "plastic material" , "Cannabis, say" , "It's obtained from tree-sap" .)