Satisfy female poorly (4)
I believe the answer is:
fill
'satisfy' is the definition.
(I know that satisfy can be written as fill)
'female poorly' is the wordplay.
'female' becomes 'f' (common abbreviation).
'poorly' becomes 'ill' (synonyms).
'f'+'ill'='FILL'
(Other definitions for fill that I've seen before include "` `Work expands to .... the time available' '" , "Completely occupy" , "Occupy the whole of" , "Satisfy (a need)" , "Top up" .)