Save city’s Spanish quarter (6)
I believe the answer is:
barrio
'spanish quarter' is the definition.
(I've seen this before)
'save city's' is the wordplay.
'save' becomes 'bar' (I've seen this before).
'city' becomes 'rio' (Rio is an example**).
'bar'+'rio'='BARRIO'
(Other definitions for barrio that I've seen before include "Spanish town district" , "District in Spanish-speaking town or city" , "Town's Spanish quarter" , "Spanish-speaking area" , "Town district in Spain" .)