"Say not the ... nought availeth" (Clough) (8)

I believe the answer is:

struggle

(Other definitions for struggle that I've seen before include "Strive, contend" , "Move limbs in vigorous attempt to get free" , "Uphill battle" , "Try hard to get free - labour" , "Toil" .)

I've seen this clue in The Irish Times.

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