Scatter spiders out east (8)
I believe the answer is:
disperse
'scatter' is the definition.
(I know that scatter can be written as disperse)
'spiders out east' is the wordplay.
'out' indicates anagramming the letters (out can mean wrong or inaccurate).
'east' becomes 'E' (synonyms).
'spiders' anagrammed gives 'dispers'.
'dispers'+'e'='DISPERSE'
(Other definitions for disperse that I've seen before include "Thin out and disappear" , "Broadcast" , "'Break up, spread out (8)'" , "Scatter, dispel" , "Scatter, disseminate" .)