School sited between Derby and Oxford, initially (4)
I believe the answer is:
eton
'school' is the definition.
(famous UK public school)
I don't understand the rest of the clue.
(Other definitions for eton that I've seen before include "Famous college" , "College in Berkshire" , "Public school founded in 1440" , "Public school near Windsor" , "Public school (sounds like 20)" .)