Scoffed at opening of Spam, preserved (7)
I believe the answer is:
scorned
'scoffed' is the definition.
'opening of spam preserved' is the wordplay.
'opening of' says to take the initial letters.
'preserved' becomes 'corned' (corning is a kind of preserving).
The first letter of 'spam' is 's'.
's'+'corned'='SCORNED'
'at' is the link.
(Other definitions for scorned that I've seen before include "Derided" , "''Hell hath no fury like a woman .. . . . . .''" , "Treated with contempt" , "Dismissed" .)