Scoundrel makes wife vomit (6)
I believe the answer is:
wretch
'scoundrel' is the definition.
(thesaurus)
'wife vomit' is the wordplay.
'wife' becomes 'w'.
'vomit' becomes 'retch' (I've seen this before).
'w'+'retch'='WRETCH'
'makes' is the link.
(Other definitions for wretch that I've seen before include "Swine" , "Good-for-nothing" , "Scoundrel" , "Contemptible person" , "Unfortunate, miserable person" .)