Screams, mixed up with a slaughter (8)
I believe the answer is:
massacre
'slaughter' is the definition.
(I know that slaughter can be written as massacre)
'screams mixed up with a' is the wordplay.
'mixed up with' indicates anagramming the letters.
'screams' mixed up with 'a' can make 'MASSACRE'.
(Other definitions for massacre that I've seen before include "Heavily defeat" , "Wanton slaughter" , "Brutal slaughter" , "Kill" , "Mass murder" .)