Screwed up large stopper to protect drum (7)
I believe the answer is:
earplug
'stopper to protect drum' is the definition.
(earplugs protect eardrums)
'screwed up large' is the wordplay.
'screwed' is an anagram indicator.
'up'+'large'='uplarge'
'uplarge' anagrammed gives 'EARPLUG'.
(Other definitions for earplug that I've seen before include "Protection against noise" , "protection for delicate drum" , "Hearing protector" , "protection from racket" , "Lug stopper?" .)