Scrub Charlie clean somehow (6)
I believe the answer is:
cancel
'scrub' is the definition.
(thesaurus)
'charlie clean somehow' is the wordplay.
'charlie' becomes 'c' (phonetic alphabet: alpha, bravo, charlie etc.).
'somehow' is an anagram indicator.
'clean' with letters rearranged gives 'ancel'.
'c'+'ancel'='CANCEL'
(Other definitions for cancel that I've seen before include "Officially prevent happening" , "Go for an annulment" , "Annul or call off" , "Cross out or annul" , "Cross out or abolish" .)