Scrub part of church, not hotel (6)
I believe the answer is:
cancel
'scrub' is the definition.
(thesaurus)
'part of church not hotel' is the wordplay.
'part of church' becomes 'chancel' ('chancel' is part of 'church').
'not' indicates named letters should be taken away.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'chancel' with 'h' taken out is 'CANCEL'.
(Other definitions for cancel that I've seen before include "Write off" , "Strike out" , "Rescind, abolish" , "Go for an annulment" , "Annul or call off" .)