Second affected international dish (6)
I believe the answer is:
scampi
'dish' is the definition.
(scampi is a kind of dish)
'second affected international' is the wordplay.
'second' becomes 's' (common abbreviation).
'affected' becomes 'camp' (I've seen this before).
'international' becomes 'i' (abbreviation eg in IMF).
's'+'camp'+'i'='SCAMPI'
(Other definitions for scampi that I've seen before include "Dish of cooked shrimps or prawns" , "sort of seafood" , "Norway lobsters -- Dublin Bay prawns" , "Cooked Norway lobsters" , "Crumby seafood dish" .)