Second largest city in New York state (7)

I believe the answer is:

buffalo

(Other definitions for buffalo that I've seen before include "Wild ox or bison" , "Large, shaggy, brown bison" , "Colloquialism for the N American bison" , "Brown bison of North American plains" , "Ox with swept-back horns" .)

I've seen this clue in The Guardian.

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