Second-largest spotted cat in South America (6)

I believe the answer is:

ocelot

(Other definitions for ocelot that I've seen before include "Wild cat, native to Central and South America - loo etc (anag)" , "Nocturnal wild cat of Central and South America" , "Striped and spotted wildcat" , "Fur" , "American cat, like a small leopard" .)

I've seen this clue in the LA Times.

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