Second person once without clothes (4)
I believe the answer is:
thou
'second person once' is the definition.
(historical second person pronoun)
'without clothes' is the wordplay.
'clothes' indicates a hidden word (the letters clothe the hidden word).
'THOU' is hidden within 'without'.
(Other definitions for thou that I've seen before include "You (obs.)" , "You (archaic, but still used in prayers)" , "Subject" , "Small measurement" , "Prominent pronoun of the King James Bible; the modern-day 'you'" .)