Secretary off again to land of giants (9)
I believe the answer is:
patagonia
'land of giants' is the definition.
The answer and definition can be both locations as well as being singular nouns.
Maybe you can see an association between them that I don't see?
'secretary off again to' is the wordplay.
'secretary' becomes 'PA' (abbreviation for personal assistant).
'off' is an anagram indicator.
'again'+'to'='againto'
'againto' is an anagram of 'tagonia'.
'pa'+'tagonia'='PATAGONIA'
Can you help me to learn more?
(Other definitions for patagonia that I've seen before include "far-off land" , "Craggy region" , "Southernmost region of S America" , "Region of southern Argentina and Chile" , "Region of South America" .)