Section of Giotto picture is item for discussion (5)
I believe the answer is:
topic
'item for discussion' is the definition.
(I've seen this in another clue)
'section of giotto picture is' is the wordplay.
'section of' indicates a hidden word.
'TOPIC' is hidden within 'giotto picture is'.
(Other definitions for topic that I've seen before include "Theme of discourse" , "one discussed" , "Subject matter of a conversation or discussion" , "'Theme, subject (5)'" , "That may be debatable" .)