Section of Manhattan (4)
I believe the answer is:
soho
'section of manhattan' is the definition.
(I know this)
This is all the clue.
(Other definitions for soho that I've seen before include "Central London entertainment area" , "Nightclub area in London" , "London's former Bohemia" , "Colourful show-biz area of West End London" , "fashionable neighbourhood (or neighborhood)" .)