See a change without difficulty (4)
I believe the answer is:
ease
'without difficulty' is the definition.
(I've seen this in other clues)
'see a change' is the wordplay.
'change' indicates anagramming the letters.
'see'+'a'='seea'
'seea' anagrammed gives 'EASE'.
(Other definitions for ease that I've seen before include "Alleviate" , "At this, one is relaxed" , "nonchalance!" , "Freedom from worries" , "Reduce (pain)" .)