See a sign of dental trouble (6)
I believe the answer is:
caries
'dental trouble' is the definition.
Although both the answer and definition are singular nouns, I can't see how they can define each other.
'see a sign' is the wordplay.
'see' becomes 'c' (the word for the letter, according to Chambers).
'a sign' becomes 'aries' (star sign).
'c'+'aries'='CARIES'
'of' is the link.
Can you help me to learn more?
(Other definitions for caries that I've seen before include "Decay in bones or teeth (6)" , "Decayed areas in teeth" , "Decay of bone or teeth" , "Dental cavities" , "Dental decay" .)