See an outsize lettuce (3)
I believe the answer is:
cos
'lettuce' is the definition.
(cos is a kind of lettuce)
'see an outsize' is the wordplay.
'see' becomes 'c' (the word for the letter, according to Chambers).
'an outsize' becomes 'os'.
'c'+'os'='COS'
(Other definitions for cos that I've seen before include "Mozart fidelity-test opera" , "leaves > function" , "Greek island (alternative spelling): Trig abbrev!" , "foreign island" , "often associated with sin" .)