Seeing that, I give up (6)
I believe the answer is:
forego
'give up' is the definition.
'seeing that i' is the wordplay.
'seeing that' becomes 'for' (both can mean 'because').
'i' becomes 'ego' (I've seen this before**).
'for'+'ego'='FOREGO'
(Other definitions for forego that I've seen before include "Get ahead" , "Take precedence" , "Surrender" , "Go without or precede" , "Go without (something desirable)" .)