Seeing that transgression, curate loses heart entirely (5)
I believe the answer is:
since
'seeing that transgression curate loses heart entirely' is the definition.
'since' can be an answer for 'seeing' (I've seen this before). I'm not sure about the rest of the definition.
'seeing that transgression curate loses heart' is the wordplay.
'seeing that transgression' becomes 'sin' (sin is a kind of transgression).
'loses heart' says to hollow out the word (remove centre letters).
'curate' with its centre removed is 'ce'.
'sin'+'ce'='SINCE'
Can you help me to learn more?
(Other definitions for since that I've seen before include "Because; ago" , "in the past" , "From that time one" , "Seeing that" .)