Seem pleased, yet turn up with a growl (4)
I believe the answer is:
purr
'seem pleased yet' is the definition.
I can't judge whether this definition defines the answer.
'turn up with a growl' is the wordplay.
'turn' is a reversal indicator.
'with' is a charade indicator (letters next to each other).
'a growl' becomes 'rr' (I can't justify this - if you can you should give a lot more credence to this answer).
'up' back-to-front is 'pu'.
'pu'+'rr'='PURR'
Can you help me to learn more?
(Other definitions for purr that I've seen before include "Sound of a contented feline" , "Make low, contented sound" , "Satisfaction from queen" , "Soft sound from car or cat" , "Sound like happy cat" .)