Self-restraint sent most of cabinet mad (10)
I believe the answer is:
abstinence
'self-restraint' is the definition.
(thesaurus)
'sent most of cabinet mad' is the wordplay.
'most of' means to remove the last letter.
'mad' indicates an anagram.
'cabinet' with its last letter taken off is 'cabine'.
'sent'+'cabine'='sentcabine'
'sentcabine' is an anagram of 'ABSTINENCE'.
(Other definitions for abstinence that I've seen before include "Practice of refraining (from alcohol)" , "giving it up" , "Going without" , "Staying away from" , "Temperance" .)