Self-obsessed jerks get on with Circe (10)
I believe the answer is:
egocentric
'self-obsessed' is the definition.
(I've seen this before)
'jerks get on with circe' is the wordplay.
'jerks' is an anagram indicator (I've seen 'jerk' mean this).
'with' is a charade indicator (letters next to each other).
'get'+'on'='geton'
'geton' after 'circe' is 'circegeton'.
'circegeton' is an anagram of 'EGOCENTRIC'.
(Other definitions for egocentric that I've seen before include "Self-obsessed" , "Self-centred person with little regard for others" , "Self-seeking" , "Selfish" , "Self-absorbed" .)