Sense changes in German city (5)
I believe the answer is:
essen
'german city' is the definition.
(city in Germany)
'sense changes' is the wordplay.
'changes' is an anagram indicator.
'sense' anagrammed gives 'ESSEN'.
'in' is the link.
(Other definitions for essen that I've seen before include "Industrial city of northwest Germany" , "German industrial centre" , "German place name" , "Main industrial city of the Ruhr" , "European city" .)