Sense single man's suffering from futility (15)
I believe the answer is:
meaninglessness
'futility' is the definition.
(thesaurus)
'sense single man's suffering' is the wordplay.
'suffering' is an anagram indicator.
'sense'+'single'+'mans'='sensesinglemans'
'sensesinglemans' with letters rearranged gives 'MEANINGLESSNESS'.
'from' acts as a link.
I've seen this clue in The Guardian.
Want a hint initially instead of a full solution?
Install my app