Separated from wife, watch out for gossip (4)
I believe the answer is:
chat
'for gossip' is the definition.
(synonyms)
'separated from wife watch out' is the wordplay.
'separated from' indicates named letters should be taken away.
'wife' becomes 'w' (abbreviation).
'out' is an anagram indicator (out can mean wrong or inaccurate).
'watch' with 'w' taken out is 'atch'.
'atch' with letters rearranged gives 'CHAT'.
(Other definitions for chat that I've seen before include "Talking" , "(13) [FRENCH] Cat" , "Bird - talk easily" , "waffle?" , "Have friendly informal conversation" .)