Set out from Scottish island, extremely game (7)
I believe the answer is:
arrange
'set out' is the definition.
'scottish island extremely game' is the wordplay.
'scottish island' becomes 'arran' (I've seen this before**).
'extremely' says to hollow out the word (remove centre letters).
'game' with its middle removed is 'ge'.
'arran'+'ge'='ARRANGE'
'from' is the link.
(Other definitions for arrange that I've seen before include "Organise, plan" , "Set in order" , "Bring about or put in order" , "Put in neat order" , "position" .)