Set up employment structure (9)
I believe the answer is:
framework
'structure' is the definition.
(I know that structure can be written as framework)
'set up employment' is the wordplay.
'set up' becomes 'frame' (synonyms).
'employment' becomes 'work' (synonyms).
'frame'+'work'='FRAMEWORK'
(Other definitions for framework that I've seen before include "Underlying structure" , "Structure, skeleton" .)