Setback for Lebanon, having lost an illustrious prize (5)
I believe the answer is:
nobel
'prize' is the definition.
(thesaurus)
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for nobel that I've seen before include "and 21 Across: Prestigious international award" , "Alfred --, Swedish founder of international prizes" , "he provided prizes" , "Philanthropic Swede noted for establishing international prizes" , "Swedish prize" .)