Setter featuring in grandma's picture (5)
I believe the answer is:
aspic
'setter' is the definition.
(I've seen this before)
'in grandma's picture' is the wordplay.
'in' indicates the answer is hidden within the clue.
'ASPIC' is hidden in the letters of 'grandmas picture'.
'featuring' acts as a link.
(Other definitions for aspic that I've seen before include "Savoury jelly for meat or vegetable" , "Clear savoury jelly" , "Setter" , "stock production" , "Jelly based on fish or meat stock" .)