Setter on the loose in road (6)
I believe the answer is:
street
'road' is the definition.
(I know that road can be written as street)
'setter on the loose' is the wordplay.
'on the loose' indicates anagramming the letters.
'setter' with letters rearranged gives 'STREET'.
'in' is the link.
(Other definitions for street that I've seen before include "See 1 Down" , "Road lined with buildings" , "Road lined with houses" , "Acceptability amongst the 'with it' young" , "- Arab; - light" .)