Setter's born with hollow urge to impregnate (5)
I believe the answer is:
imbue
'impregnate' is the definition.
(thesaurus)
'setter's born with hollow urge' is the wordplay.
'setter's' becomes 'im' (I've seen this in other clues**).
'born' becomes 'b'.
'with' says to put letters next to each other.
'hollow' suggests removing the centre.
'urge' with its centre removed is 'ue'.
'im'+'b'+'ue'='IMBUE'
'to' acts as a link.
(Other definitions for imbue that I've seen before include "Fill with, infuse" , "Fill (with a particular feeling)" , "Steep" , "Permeate, pervade" , "Charge" .)