Sew? Mean to go round end of skirt (5)
I believe the answer is:
baste
'sew?' is the definition.
(basting is a kind of sewing)
'mean to go round end of skirt' is the wordplay.
'mean' becomes 'base' (synonyms).
'to go round' is an insertion indicator.
'end of' suggests the final letters.
The last letter of 'skirt' is 't'.
'base' going around 't' is 'BASTE'.
(Other definitions for baste that I've seen before include "Pour hot oil on to cook" , "Beat" , "Looking at with interest" , "Pour fat over meat during cooking" , "Pour hot cooking juices over" .)