Shake a big drink to get male drunk (7)
I believe the answer is:
tremble
'shake' is the definition.
(I know that shake can be written as tremble)
'a big drink to get male drunk' is the wordplay.
'a big drink' becomes 'treble' (as opposed to a single or double).
'to get male' becomes 'm' (I am not sure about this - if you are sure you should believe this answer much more).
'drunk' indicates putting letters inside (inserted letters are drunk in).
'treble' placed around 'm' is 'TREMBLE'.
(Other definitions for tremble that I've seen before include "get the shakes" , "Shake with fright or cold" , "Show fear" , "Shake involuntarily" , "Look nervous" .)