Shake oil paint apt to run (11)
I believe the answer is:
palpitation
'shake' is the definition.
(thesaurus)
'oil paint apt to run' is the wordplay.
'to run' indicates an anagram.
'oil'+'paint'+'apt'='oilpaintapt'
'oilpaintapt' with letters rearranged gives 'PALPITATION'.
(Other definitions for palpitation that I've seen before include "quivery state" , "Rapid irregular heartbeat" .)